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olchemim Cyclin-dependent kinase inhibitors

發(fā)布時間：2024-06-13

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公司地址：廣州市天河區(qū)天河北路僑林街47號中旅商務(wù)大廈東塔25E

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Molecules that play key roles in controlling cell-cycle progression are the cyclin-dependent kinase (CDK). Research focused on the primary mechanism of cytokinin action in cell division cycle has showed that natural cytokinins are rather non-specific inhibitors of various kinases. Surprisingly, among cytokinin derivatives, a BAP derivative named olomoucin (OC), which specifically inhibits some CDKs at micromolar concentration.

OLOMOUCINE [6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine]

MW 298.35, crystalline, purity > 98% (HPLC)
S:26, 36; CAS: 101622-51-9; C₁₅H₁₈N₆O

	008 0211	10	mg
	008 0212	20	mg
	008 0213	100	mg
	008 0214	1	mg

BOHEMINE [6-benzylamino-2-(3-hydroxypropylamino)-9-isopropylpurine]

MW 340.43, crystalline, purity > 98% (HPLC)
IC₅₀ value for CDK1: 1 µM
S:26, 36; CAS: 189232-42-6; C₁₈H₂₄N₆O

	008 0771	5	mg
	008 0772	10	mg
	008 0773	50	mg

2-HYDROXYBOHEMINE (HOB) [6-(2-hydroxybenzylamino)-2-(3-hydroxypropylamino)-9-isopropylpurine]

MW 356.43, crystalline, purity > 98% (HPLC)
IC₅₀ value for CDK1: 0.1 µM
S:26, 36; CAS: 471270-60-7; C₁₈H₂₄N₆O₂

	008 5931	5	mg
	008 5932	10	mg
	008 5933	50	mg

ISOPROPYL-OLOMOUCINE [6-benzylamino-2-(2-hydroxyethylamino)-9-isopropylpurine]

MW 326.40, crystalline, purity > 98% (HPLC)
IC₅₀ value for CDK1: 2 µM
S:26, 36; CAS: 158982-15-1; C₁₇H₂₂N₆O

	008 0781	5	mg
	008 0782	10	mg
	008 0783	50	mg

ISO-OLOMOUCINE [6-benzylamino-2-(2-hydroxyethylamino)-7-methylpurine]

MW 298.35, crystalline, purity > 98% (HPLC)
Inactive 7-isomer of olomoucine.
IC₅₀ value for CDK1: 200 µM
S:26, 36; CAS: 101622-50-8; C₁₅H₁₈N₆O

	008 0791	5	mg
	008 0792	10	mg
	008 0793	50	mg

OLOMOUCINE II [6-(2-hydroxybenzylamino)-2(R)-[1-(hydroxymethyl)propyl]amino-9-isopropylpurine]

MW 370.46, crystalline, purity > 98% (HPLC)
IC₅₀ value for CDK1: 0.02 µM
S:26, 36; CAS: 500735-47-7; C₁₉H₂₆N₆O₂

	008 5261	5	mg
	008 5262	10	mg
	008 5263	50	mg

RS-ROSCOVITINE [6-benzylamino-[2-(1(RS)-(hydroxymethyl)propyl]amino-9-isopropylpurine]

MW 354.45, crystalline, purity > 98% (HPLC)
IC₅₀ value for CDK1: 0.45 µM
S:26, 36; CAS: 186692-44-4; C₁₉H₂₆N₆O

	008 0361	5	mg
	008 0362	10	mg
	008 0363	50	mg

R-ROSCOVITINE 6-benzylamino-2-[1(R)-(hydroxymethyl)propyl]amino-9-isopropylpurine]

MW 354.45, crystalline, purity > 98% (HPLC)
IC₅₀ value for CDK1: 0.2 µM
S:26, 36; CAS: 186692-46-6; C₁₉H₂₆N₆O

	008 5741	5	mg
	008 5742	10	mg
	008 5743	50	mg

S-ROSCOVITINE [6-benzylamino-2-[1(S)-(hydroxymethyl)propyl]amino-9-isopropylpurine]

MW 354.45, crystalline, purity > 98% (HPLC)
IC₅₀ value for CDK1: 0.6 µM
S:26, 36; CAS: 186692-45-5; C₁₉H₂₆N₆O

	008 5751	5	mg
	008 5752	10	mg
	008 5753	50	mg

PURVALANOL A [6-(3-chlorophenyl)amino-2-[1(R)-(hydroxymethyl)-2-(methyl)propyl]amino-9-isopropylpurine]

MW 388.90, crystalline, purity > 98% (HPLC)
S:26, 36; CAS: 212844-53-6; C₁₉H₂₅ClN₆O

	008 0851	5	mg
	008 0852	10	mg
	008 0853	50	mg

AMINOPURVALANOL (APURV) [(R)-2-[6-(3-amino-5-chlorophenylamino)-9-isopropyl-9H-purin-2-ylamino]-3-methyl-butan-1-ol]

MW 403.91, crystalline, purity > 98% (HPLC)
R:22, S:22, 24/25; CAS: 220792-57-4; C₁₉H₂₆ClN₇O

	008 5951	5	mg
	008 5952	10	mg
	008 5953	25	mg

MYOSEVERIN [9-isopropyl-2,6-bis(4-methoxybenzylamino)purine]

MW 432.53, crystalline, purity > 98% (HPLC)
S:26, 36; CAS: 267402-71-1; C₂₄H₂₈N₆O₂

	008 0861	5	mg
	008 0862	10	mg
	008 0863	50	mg

2-CHLORO-6-BENZYLAMINO-9-ISOPROPYLPURINE

MW 301.78, crystalline, purity > 98% (HPLC)
S:26, 36; CAS: 186692-41-1; C₁₅H₁₆ClN₅

	008 5271	50	mg
	008 5272	100	mg
	008 5273	250	mg
	008 5274	1	g

2-CHLORO-6-BENZYLAMINO-7-METHYLPURINE

MW 273.73, crystalline, purity > 98% (HPLC)
S:26, 36; CAS: 101622-52-0; C₁₃H₁₂ClN₅

	008 5281	10	mg
	008 5282	50	mg
	008 5283	100	mg

2-CHLORO-6-BENZYLAMINO-9-METHYLPURINE

MW 273.73, crystalline, purity > 98% (HPLC)
S:26, 36; CAS: 101622-53-1; C₁₃H₁₂ClN₅

	008 5291	50	mg
	008 5292	100	mg
	008 5293	250	mg
	008 5294	1	g

2-CHLORO-6-(ISOPENT-2-ENYLAMINO)-9-METHYLPURINE

MW 251.72, crystalline, purity > 98% (HPLC)
S:26, 36; CAS: 189232-32-4; C₁₁H₁₄ClN₅

	008 5301	50	mg
	008 5302	100	mg
	008 5303	250	mg
	008 5304	1	g

CVT 313

MW 400.48, crystalline, purity > 98% (HPLC)
S:26, 36; CAS: 199986-75-9; C₂₀H₂₈N₆O₃

	008 5761	5	mg
	008 5762	10	mg
	008 5763	50	mg

NG 38 [2-(1-piperenidinyl)-6-(3-nethoxybenzylamino)-9-isopropylpurine]

MW 380.50, crystalline, purity > 98% (HPLC)
S:26, 36; CAS: NONE; C₂₁H₂₈N₆O

	008 5911	5	mg
	008 5912	10	mg
	008 5913	50	mg

2-(2-HYDROXYETHYLAMINO)-6-(ISOPENT-2-ENYLAMINO)-9-METHYLPURINE

MW 276.34, crystalline, purity > 98% (HPLC)
S:26, 36; CAS: 158982-16-2; C₁₃H₂₀N₆O

	008 5311	5	mg
	008 5312	10	mg
	008 5313	50	mg

INDIRUBIN [3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one]

MW 260.27, crystalline, purity > 98% (HPLC)
S:26, 36; CAS: 479-41-4; C₁₆H₁₀N₂O₂
IC₅₀ value for CDK1: 10 µM

	008 5831	5	mg
	008 5832	10	mg
	008 5833	50	mg

INDIRUBIN-5’-SULPHONIC ACID [3,2'-dioxo-1,3,1',2'-tetrahydro-[2,3']biindolylidene-5'-sulfonic acid]

MW 342.33, crystalline, purity > 98% (HPLC)
S:26, 36; CAS: 864131-82-8; C₁₆H₁₀N₂O₅S
IC₅₀ value for CDK1: 0.055 µM

	008 5841	5	mg
	008 5842	10	mg
	008 5843	50	mg

INDIRUBIN-3’-MONOOXIME [1H,1'H-[2,3']bisindolylidene-3,2'-dione 3-oxime]

MW 277.28, crystalline, purity > 98% (HPLC)
S:26, 36; CAS: 160807-49-8; C₁₆H₁₁N₃O₂
IC₅₀ value for CDK1: 0.18 µM

	008 5851	5	mg
	008 5852	10	mg
	008 5853	50	mg

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